“Losing patience” with the unvaxxed vs playing with the fire of “leaky” vaccines

Contribution 128/‘21 # 20)

Have we put the cart before the horse with this pandemic, as leaky vaxxes can trigger the rapid spread of more dangerous strains? (And so, back to the value of Ivermectin.)

BRADES, Montserrat, September 12, 2021 – It is clear that some health authorities and governments across the Caribbean and wider world are beginning to “lose patience” with the not vaccinated. Such are widely viewed as misinformed, as idiotic,[1] stubborn, led by armchair instigators, as a dangerous source of spreading the pandemic, even as irresponsible and antisocial. Street talk and social media buzz show that some here in Montserrat are catching the impatience fever. We need to cool down the temperature and show why effective treatments such as Ivermectin are a key strategy.

Marek’s Disease in Chickens, a model for immunity escape
[Cr Kumawat, Slideshare]

For, there is a Marek’s Disease Virus[2] shaped reason why Pfizer’s CEO recently touted his bright shiny new pill and finally publicly admitted that “Success against #COVID19 will likely require both vaccines & treatments.”[3]For, here in Montserrat, across the region and the world, we are playing with the fire of “leaky,” “non-sterilising” vaccines.

The case of Marek’s Disease Virus in chickens – yes, chickens – tells us why.

Andrew F Read et al. let the cat out of the bag,  in PLOS Biology, back in July 2015[4]:

“Vaccines that keep hosts alive but still allow transmission could . . .  allow very virulent strains to circulate in a population. Here we show experimentally that immunization of chickens against Marek’s disease virus enhances the fitness of more virulent strains . . . . When vaccines prevent transmission, as is the case for nearly all vaccines used in humans, this type of evolution towards increased virulence is blocked. But when vaccines leak, allowing at least some pathogen transmission, they could create the ecological conditions that would allow hot strains to emerge and persist . . . [W]e report experiments with Marek’s disease virus in poultry that show that modern commercial leaky vaccines can have precisely this effect: they allow the onward transmission of strains otherwise too lethal to persist. Thus, the use of leaky vaccines can facilitate the evolution of pathogen strains that put unvaccinated hosts at greater risk of severe disease.”

The article also notes that:

“Efficacy and mode of action are key. If [a] vaccine is sterilizing, so that transmission is stopped, no evolution can occur. But if it is non-sterilizing, so that naturally acquired pathogens can transmit from immunized individuals (what we hereafter call a “leaky” vaccine), virulent strains will be able to circulate in situations in which natural selection would have once removed them . . .” 

It is of course obvious that local, regional and international officials recognise that the major Covid-19 vaccines (including the AstraZeneca used in Montserrat) are “non-sterilising.” That’s why the vaccinated have continued to be tested and quarantined. That’s why they must still wear face masks and do social distancing etc. That’s why it is admitted they can catch and infect others with the disease, though it is believed that the vaccines reduce the intensity of the disease. And, it is why, with Delta strain on the loose, we see significant numbers of cases where the “fully vaccinated” are becoming seriously ill or worse with Covid-19. So, again, as a recent report on Israel (which is now pushing third jabs) noted[5]:

“As of 15 August, 514 Israelis were hospitalized with severe or critical COVID-19 . . . 59% were fully vaccinated. Of the vaccinated, 87% were 60 or older. “There are so many breakthrough infections that they dominate and most of the hospitalized patients are actually vaccinated,”  says Uri Shalit, a bioinformatician at the Israel Institute of Technology (Technion) . . . “One of the big stories from Israel is:

‘Vaccines work, but not well enough.’” [“A grim warning from Israel: Vaccination blunts, but does not defeat Delta” Science Mag dot Org, August 16, 2021.]

In short, those who are “losing patience” with the unvaxxed have put the cart before the horse and are sliding into blaming the victim.

It was obvious from the beginning that the major anti-Covid-19 vaccines were “leaky” or “non-sterilising.” The researchers, regulators, and officials all knew that. We can take it to the bank that they knew about the Marek Virus evidence, that leaky vaxxes can turn the vaxxed into reservoirs for more dangerous, more infectious, fast-spreading strains than would naturally have come about. So, we know one reason they are desperate to get everyone jabbed, they fear a  truly lethal breakout strain, let’s call it Delta-plus. But we are not locked up in such a dilemma. There is the Ivermectin-based treatment option that should have been vigorously pushed as the treatment arm of our pandemic strategy for many months now.

But, someone following the WHO-FDA talking points,[6] may say, there’s no scientific evidence of that.

False, irresponsibly, destructively, inexcusably false, with lives on the line.

For one example, here are Omura et al from Japan, in a review article published in March this year[7] – yes, six months ago:

 “As of the 30th  of January 2021, a total of 91 trials in 27 countries has been recorded at these registration sites. There are 43 trials in phase 3 and 27 trials in phase 2, along with 17 observational studies. This includes 80 trials being conducted for therapeutic purposes and 11 for the purpose of preventing the onset of disease in close contacts and healthcare professionals. Furthermore,  by the 27th of February, the results of 42  clinical trials,  including approximately 15,000 patients (both registered and unregistered studies) have been subjected to a meta-analysis after exclusion of biasing factors. It was found that 83% showed improvements with early treatment,  51%  improved during late-stage treatment, and there was an 89% prevention of onset rate noted. This confirms the usefulness of ivermectin. Since it is a meta-analysis based on 42 test results, it is estimated that the probability of this comprehensive judgment being a mistake is as low  as one  in  four  trillion.” [The Japanese Journal of Antibiotics 74-1. Ivermectin emerged from research done in Japan.]

Investors and gamblers would salivate over an opportunity to bet with odds of four million, millions to one in favour of success. That is far more than adequate, robust scientific evidence to allow physicians to prescribe Ivermectin as a preventative, as a treatment to stamp out early-stage Covid-19, and even as part of protocols for seriously ill patients.[8] Those who have pretended otherwise have done the world a grave disservice.

It is time for a fresh conversation and a fresh approach to taming the pandemic before it becomes an even more destructive immune escape monster, say, Delta-plus. That is going to require that we back away from the WHO-FDA talking points and recognise the evidence for and legitimacy of treatments based on repurposed, proved medications such as Ivermectin.


[1]TMR https://www.themontserratreporter.com/failing-the-horse-de-wormer-test/

[2] See https://extension.psu.edu/mareks-disease-in-chickens-description-and-prevention

[3] See https://twitter.com/AlbertBourla/status/1433024869168558081?ref_src=twsrc%5Etfw

[4] See PLOS Biology https://journals.plos.org/plosbiology/article/info:doi/10.1371/journal.pbio.1002198

[5] TMR https://www.themontserratreporter.com/covid-19-vaccine-trends-concerns-and-misinformation/ see also https://www.sciencemag.org/news/2021/08/grim-warning-israel-vaccination-blunts-does-not-defeat-delta 

[6]See FLCCC point by point response https://covid19criticalcare.com/wp-content/uploads/2021/05/CLEAN-FLCCC-STATEMENT-AGAINST-THE-GLOBAL-IVERMECTIN-DISINFORMATION-CAMPAIGN-5.11.2021.pdf

[7] See JJA http://jja-contents.wdc-jp.com/pdf/JJA74/74-1-open/74-1_44-95.pdf

[8] See https://covid19criticalcare.com/covid-19-protocols/

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Contribution 128/‘21 # 20)

Have we put the cart before the horse with this pandemic, as leaky vaxxes can trigger the rapid spread of more dangerous strains? (And so, back to the value of Ivermectin.)

BRADES, Montserrat, September 12, 2021 – It is clear that some health authorities and governments across the Caribbean and wider world are beginning to “lose patience” with the not vaccinated. Such are widely viewed as misinformed, as idiotic,[1] stubborn, led by armchair instigators, as a dangerous source of spreading the pandemic, even as irresponsible and antisocial. Street talk and social media buzz show that some here in Montserrat are catching the impatience fever. We need to cool down the temperature and show why effective treatments such as Ivermectin are a key strategy.

Insert Ads Here
Marek’s Disease in Chickens, a model for immunity escape
[Cr Kumawat, Slideshare]

For, there is a Marek’s Disease Virus[2] shaped reason why Pfizer’s CEO recently touted his bright shiny new pill and finally publicly admitted that “Success against #COVID19 will likely require both vaccines & treatments.”[3]For, here in Montserrat, across the region and the world, we are playing with the fire of “leaky,” “non-sterilising” vaccines.

The case of Marek’s Disease Virus in chickens – yes, chickens – tells us why.

Andrew F Read et al. let the cat out of the bag,  in PLOS Biology, back in July 2015[4]:

“Vaccines that keep hosts alive but still allow transmission could . . .  allow very virulent strains to circulate in a population. Here we show experimentally that immunization of chickens against Marek’s disease virus enhances the fitness of more virulent strains . . . . When vaccines prevent transmission, as is the case for nearly all vaccines used in humans, this type of evolution towards increased virulence is blocked. But when vaccines leak, allowing at least some pathogen transmission, they could create the ecological conditions that would allow hot strains to emerge and persist . . . [W]e report experiments with Marek’s disease virus in poultry that show that modern commercial leaky vaccines can have precisely this effect: they allow the onward transmission of strains otherwise too lethal to persist. Thus, the use of leaky vaccines can facilitate the evolution of pathogen strains that put unvaccinated hosts at greater risk of severe disease.”

The article also notes that:

“Efficacy and mode of action are key. If [a] vaccine is sterilizing, so that transmission is stopped, no evolution can occur. But if it is non-sterilizing, so that naturally acquired pathogens can transmit from immunized individuals (what we hereafter call a “leaky” vaccine), virulent strains will be able to circulate in situations in which natural selection would have once removed them . . .” 

It is of course obvious that local, regional and international officials recognise that the major Covid-19 vaccines (including the AstraZeneca used in Montserrat) are “non-sterilising.” That’s why the vaccinated have continued to be tested and quarantined. That’s why they must still wear face masks and do social distancing etc. That’s why it is admitted they can catch and infect others with the disease, though it is believed that the vaccines reduce the intensity of the disease. And, it is why, with Delta strain on the loose, we see significant numbers of cases where the “fully vaccinated” are becoming seriously ill or worse with Covid-19. So, again, as a recent report on Israel (which is now pushing third jabs) noted[5]:

“As of 15 August, 514 Israelis were hospitalized with severe or critical COVID-19 . . . 59% were fully vaccinated. Of the vaccinated, 87% were 60 or older. “There are so many breakthrough infections that they dominate and most of the hospitalized patients are actually vaccinated,”  says Uri Shalit, a bioinformatician at the Israel Institute of Technology (Technion) . . . “One of the big stories from Israel is:

‘Vaccines work, but not well enough.’” [“A grim warning from Israel: Vaccination blunts, but does not defeat Delta” Science Mag dot Org, August 16, 2021.]

In short, those who are “losing patience” with the unvaxxed have put the cart before the horse and are sliding into blaming the victim.

It was obvious from the beginning that the major anti-Covid-19 vaccines were “leaky” or “non-sterilising.” The researchers, regulators, and officials all knew that. We can take it to the bank that they knew about the Marek Virus evidence, that leaky vaxxes can turn the vaxxed into reservoirs for more dangerous, more infectious, fast-spreading strains than would naturally have come about. So, we know one reason they are desperate to get everyone jabbed, they fear a  truly lethal breakout strain, let’s call it Delta-plus. But we are not locked up in such a dilemma. There is the Ivermectin-based treatment option that should have been vigorously pushed as the treatment arm of our pandemic strategy for many months now.

But, someone following the WHO-FDA talking points,[6] may say, there’s no scientific evidence of that.

False, irresponsibly, destructively, inexcusably false, with lives on the line.

For one example, here are Omura et al from Japan, in a review article published in March this year[7] – yes, six months ago:

 “As of the 30th  of January 2021, a total of 91 trials in 27 countries has been recorded at these registration sites. There are 43 trials in phase 3 and 27 trials in phase 2, along with 17 observational studies. This includes 80 trials being conducted for therapeutic purposes and 11 for the purpose of preventing the onset of disease in close contacts and healthcare professionals. Furthermore,  by the 27th of February, the results of 42  clinical trials,  including approximately 15,000 patients (both registered and unregistered studies) have been subjected to a meta-analysis after exclusion of biasing factors. It was found that 83% showed improvements with early treatment,  51%  improved during late-stage treatment, and there was an 89% prevention of onset rate noted. This confirms the usefulness of ivermectin. Since it is a meta-analysis based on 42 test results, it is estimated that the probability of this comprehensive judgment being a mistake is as low  as one  in  four  trillion.” [The Japanese Journal of Antibiotics 74-1. Ivermectin emerged from research done in Japan.]

Investors and gamblers would salivate over an opportunity to bet with odds of four million, millions to one in favour of success. That is far more than adequate, robust scientific evidence to allow physicians to prescribe Ivermectin as a preventative, as a treatment to stamp out early-stage Covid-19, and even as part of protocols for seriously ill patients.[8] Those who have pretended otherwise have done the world a grave disservice.

It is time for a fresh conversation and a fresh approach to taming the pandemic before it becomes an even more destructive immune escape monster, say, Delta-plus. That is going to require that we back away from the WHO-FDA talking points and recognise the evidence for and legitimacy of treatments based on repurposed, proved medications such as Ivermectin.


[1]TMR https://www.themontserratreporter.com/failing-the-horse-de-wormer-test/

[2] See https://extension.psu.edu/mareks-disease-in-chickens-description-and-prevention

[3] See https://twitter.com/AlbertBourla/status/1433024869168558081?ref_src=twsrc%5Etfw

[4] See PLOS Biology https://journals.plos.org/plosbiology/article/info:doi/10.1371/journal.pbio.1002198

[5] TMR https://www.themontserratreporter.com/covid-19-vaccine-trends-concerns-and-misinformation/ see also https://www.sciencemag.org/news/2021/08/grim-warning-israel-vaccination-blunts-does-not-defeat-delta 

[6]See FLCCC point by point response https://covid19criticalcare.com/wp-content/uploads/2021/05/CLEAN-FLCCC-STATEMENT-AGAINST-THE-GLOBAL-IVERMECTIN-DISINFORMATION-CAMPAIGN-5.11.2021.pdf

[7] See JJA http://jja-contents.wdc-jp.com/pdf/JJA74/74-1-open/74-1_44-95.pdf

[8] See https://covid19criticalcare.com/covid-19-protocols/