Archive | Science/Technology

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Is this the end of COVID?

https://www.msn.com/en-gb/health/medical/is-this-the-end-of-covid/ar-AAYgkOi?ocid=winp1taskbar&cvid=afb6e10222f0468c8adfe5779fb9463a

Is this the end of Covid?

MSN Sorcha Bradley – 

Members of the public look at a wall of remembrance for Covid-19 victims Dan Kitwood
Getty Images© Dan Kitwood/Getty Images

WHO gives most upbeat assessment yet of the global battle against the virus

The end of the global Covid-19 pandemic is “in sight”, said the World Health Organization (WHO), after data revealed that worldwide weekly deaths are at their lowest level since March 2020.

In the week to 11 September, there were just under 11,000 Covid deaths, according to the WHO’s website, the lowest level since the UK entered its first national lockdown two years ago. And in the UK the number of infections has dropped to its lowest level “for nearly 11 months”, said Sky News.

WHO director-general000000000000 Dr. Tedros Adhanom Ghebreyesus said: “We have never been in a better position to end the pandemic – we are not there yet, but the end is in sight.

“We can see the finish line, we’re in a winning position. But now is the worst time to stop running. Now is the time to run harder and make sure we cross the line and reap the rewards of all our hard work.”

He added: “If we don’t take this opportunity now, we run the risk of more variants, more deaths, more disruption, and more uncertainty. So let’s seize this opportunity.” 

This is the UN agency’s “most upbeat assessment” since it declared Covid-19 an international emergency in January 2020, said Reuters. But it has warned that the virus remains an “acute global emergency” and highlighted that during the first eight months of 2022 more than a million people died from Covid-19.

The latest data

According to data from the Office for National Statistics (ONS), around 944,700 people in private households are estimated to have had coronavirus in the week to 28 August. This represents the lowest UK total since the week to 2 October 2021, when the number was 942,600.

Related video: WHO chief says end in sight for Covid-19 pandemic

WHO chief says end in sight for Covid-19 pandemicUnmute

View on Watch 

In the week ending 2 September, there were 8,868 deaths in England and Wales, of which 314 mentioned “novel coronavirus”, accounting for 3.5% of overall deaths, said The Guardian.

The paper reported that infections “hit 3.8m in early July this year during the spread of the Omicron BA.4 and BA.5 subvariants”, but these figures have been “on a broadly downward path in recent weeks”.

What drove the summer wave?

The summer wave was fuelled largely by new Omicron variants, BA.4 and BA.5, the ONS said.

Danny Altmann, a professor of immunology at Imperial College London, told The Guardian that Omicron is “poorly immunogenic, which means that catching it offers little extra protection against catching it again”.

“This suggests that even if you had Omicron during the Christmas and New Year’s wave, it is still possible that you will catch the virus again,” The Independent reported.

Another factor was “pandemic fatigue” leading to less cautious behaviour which, combined with the end to restrictions, meant people who had previously avoided Covid were more likely to catch it over the summer months.

Autumn booster campaign

While the summer wave of Covid-19 infections seems to have peaked, “another wave is anticipated in the autumn as people move inside with the colder weather”, said The Guardian.

As a result, an autumn booster campaign will offer another vaccine dose to: adults aged 50 and over; those aged five to 49 with health conditions that put them at higher risk, including pregnant women; care home staff; frontline health and social care workers; carers aged 16 to 49; and household contacts of people with weakened immune systems, said the BBC.

As well as Covid, The Guardian reported that “public health officials fear flu may bounce back hard and early this year, given the experience in Australia, making vaccinations for both flu and Covid a high priority in the autumn”.

Vaccine progress

In more welcome developments, trial results have suggested that Moderna’s new Covid-19 vaccine is five times better at boosting antibodies than its original jab.

The pharmaceutical firm said early clinical trials showed that the next-generation jab produced 9,500 units of antibody in vaccinated individuals compared to a maximum of 1,800 units with an original booster jab.

The company’s chief medical officer told The Telegraph that the new vaccine could boost a person’s antibodies to such an extent that a booster may only be needed annually.

Posted in COVID-19, Featured, Health, International, Local, Regional, Science/Technology0 Comments

Dr-John-Campbell

Encourage! – but mandate with refusal turning workers into beggars, to starvation is criminal

Will the perpetrators pay? Don’t wait… they or theirs will pay!

Dr John Campbell

Posted in COVID-19, Featured, International, Local, News, Regional, Science/Technology0 Comments

image-1

Fight with Vitamin D – in Israel with Dr. John Campbell

Vitamin D in Israel!

Dr. John Campbell
Dr. Michael Cohen

This video is for educational purposes only and must not replace advice from your own health care provider. Always consult your own doctor before taking any medication or supplements.
Dr. Michael Cohen discusses the importance of Vitamin D and zinc for the optimisation of the immune system. Vitamin K2 is also used to distribute calcium to the correct tissues.
Thank you Dr. Cohen for this excellent explanation of preventing and minimising infection by enabling the amazing natural immune response.
Dr. Cohan, Surgery details

As the Government and medical authorities only continue to push getting the vaccines, and otherwise do not guide and advise on the lives they pretend to protect; the people who for one reason or another who are able to think beyond, their survival of the ‘pandemic’, here is help to strengthen their resolve.

Preparing to fight COVID-19 (viruses)
Much to learn for you and your responsibilties own lives
The UK makes plans for the possible onslaught of Omicron
Has this problem been resolved?

Posted in COVID-19, Education, Featured, Health, International, Local, News, Regional, Science/Technology, Videos0 Comments

MedicalNewsToday-logo

Vaccines protect from severe disease but do not stop all transmission

New research examines the risk of household transmission of the Delta variant, despite vaccination. Christopher Furlong/Getty Images

TMR Adapted

https://www.medicalnewstoday.com/

https://www.medicalnewstoday.com/articles/delta-variant-vaccines-protect-from-severe-disease-but-do-not-stop-all-transmission

  • The COVID-19 vaccine effectively prevents severe illness and death.
  • The Delta (B.1.617.2) variant of SARS-CoV-2 is spreading globally in populations with high vaccination rates.
  • 1 in 4 fully vaccinated people who have exposure to the Delta variant in the home are likely to get the infection.
  • The peak viral load of the Delta virus does not differ between fully vaccinated and nonvaccinated individuals.
  • The elimination of the Delta strain of the virus takes place more quickly in vaccinated individuals.

The SARS-CoV-2 Delta variantTrusted Source is the most widely spread variation of the virus, accounting for about 99.8% of cases in the United Kingdom. The highly transmissible Delta variant is spreading globally, including in populations with high vaccination rates.

Several studies have shown the effectiveness of the COVID-19 vaccines in protecting from severe disease and death. Research has also confirmed that fully vaccinated individuals have a lower risk of infection with both the Alpha (B.1.1.7)Trusted Source and Delta variants compared with unvaccinated people.

However, to date, vaccination has not limited the spread of the Delta variant. A new study, which appears in The Lancet Infectious DiseasesTrusted Source, has found that vaccination alone is not enough to stop the household transmission of the Delta variant.

Researchers from Imperial College London, the UK Health Security Agency, and the Manchester Foundation NHS Trust collaborated to carry out this “real life” study of household transmission in the U.K.

Vaccines are ‘not a silver bullet’

The researchers recruited 621 people over 12 months from Sept 2020. Of these individuals, 163 (26%) had a SARS-CoV-2 infection. The team used genome sequencing to identify the variant:

  • 71 participants had a Delta variant infection
  • 42 had an Alpha variant infection
  • 50 had a pre-Alpha variant infection

The scientists used the secondary attack rate (SAR)Trusted Source to study the spread of the SARS-CoV-2 virus in households. The SAR for exposed household contacts for the Delta variant was 26%, regardless of vaccination status. However, the researchers found that 25% of vaccinated household contacts tested positive for the SARS-CoV-2 Delta virus compared with roughly 38% of unvaccinated household contacts.

Dr. Simon Clarke, who is an associate professor in cellular microbiology at the University of Reading and was not involved in the study, says:

“These findings show that the vaccines remain an effective way to drive down [SARS-CoV-2] infection, but they are not a silver bullet. Infection in the wider community can still be amplified by transmission at home.”

The ability of the vaccine to prevent infection with the Delta variant in the household was roughly 34%.

Interestingly, the study found vaccination status to have no effect on the maximum amount of the SARS-CoV-2 Delta virus present, known as the peak viral load. Other studies have found similar viral loads in nasal swabs, irrespective of vaccine status.

“These similar peak viral loads in vaccine breakthrough infections may explain why infected vaccinated people were just as likely to pass on infection as infected unvaccinated people,” says Prof. Peter Openshaw, professor of experimental medicine at Imperial College London.

Despite no difference in viral load, the body reduced the amount of SARS-CoV-2 Delta in the airways more quickly in vaccinated people than in unvaccinated people.

How Delta can spread among vaccinated people

Speaking with Medical News TodayDr. Sarah Pitt, principal lecturer at the School of Applied Sciences, University of Brighton, explained: “What is interesting about this study is because they followed people up for 3 weeks, they could see how much virus they were shedding and for how long […]. This could be a useful finding, as it might provide new information about how long people should self-isolate for once they have tested positive.”

The researchers noted that the time between the completion of vaccination and study recruitment was longer for PCR-positive contacts than for PCR-negative contacts. This is an important finding according to Prof. Penny Ward, an independent pharmaceutical physician, visiting professor in pharmaceutical medicine at King’s College London.

She says that this may indicate that “waning individual protection may occur from 3 months rather than the 6 months currently scheduled for booster doses.”

The researchers note that they only included the contacts of symptomatic individuals in this study. Despite each of these people being the first member of their household to have a PCR-positive test, it is possible that another household member may already have had the infection.

According to Professor Emeritus Keith Neal of the University of Nottingham, this study helps with “understanding why Delta is now the predominant variant worldwide. Delta is able to spread between vaccinated people in a way previous variants did not.”

The research shows that the Delta variant of the SARS-CoV-2 virus can transmit from fully vaccinated people, who can have similar amounts of it in their airways as someone who is unvaccinated.

However, the amount of the virus in the airways of a fully vaccinated individual clears more quickly, suggesting that the risk of transmission lasts for less time than it would if they were not vaccinated.

Dr. Clarke says: “[T]he fact that a vaccine reduces someone’s chance of getting [the infection] in the first place means that while the vaccines don’t provide complete protection against transmission, they are not completely ineffective.”

For live updates on the latest developments regarding the novel coronavirus and COVID-19, click here.

Posted in COVID-19, Featured, Health, International, Local, News, Science/Technology0 Comments

 (Independent)

WhatsApp, Facebook, Instagram, seems to be having a recess – we hope…

Andrew GriffinMon, October 4, 2021, 1:31 PM

 (Independent)
(Independent)

Facebook, WhatsApp and Instagram have all gone down in a major outage.

Such problems – especially after they have been ongoing for hours – likely indicates there is a major problem with the technology underpinning Facebook’s services.

And it could last for hours. In 2019, when it suffered from its biggest-ever outage, it was more than 24 hours from the beginnings of the problem until Facebook said it was resolved.
That was on March 13, 2019…

Posted in Announcements/Greetings, Business/Economy/Banking, COVID-19, Culture, Entertainment, General, International, Local, News, Regional, Science/Technology0 Comments

Mareks-Disease-in-Chickens-a-model-for-immunity-escape-Cr-Kumawat-Slideshare-3

“Losing patience” with the unvaxxed vs playing with the fire of “leaky” vaccines

Contribution 128/‘21 # 20)

Have we put the cart before the horse with this pandemic, as leaky vaxxes can trigger the rapid spread of more dangerous strains? (And so, back to the value of Ivermectin.)

BRADES, Montserrat, September 12, 2021 – It is clear that some health authorities and governments across the Caribbean and wider world are beginning to “lose patience” with the not vaccinated. Such are widely viewed as misinformed, as idiotic,[1] stubborn, led by armchair instigators, as a dangerous source of spreading the pandemic, even as irresponsible and antisocial. Street talk and social media buzz show that some here in Montserrat are catching the impatience fever. We need to cool down the temperature and show why effective treatments such as Ivermectin are a key strategy.

Marek’s Disease in Chickens, a model for immunity escape
[Cr Kumawat, Slideshare]

For, there is a Marek’s Disease Virus[2] shaped reason why Pfizer’s CEO recently touted his bright shiny new pill and finally publicly admitted that “Success against #COVID19 will likely require both vaccines & treatments.”[3]For, here in Montserrat, across the region and the world, we are playing with the fire of “leaky,” “non-sterilising” vaccines.

The case of Marek’s Disease Virus in chickens – yes, chickens – tells us why.

Andrew F Read et al. let the cat out of the bag,  in PLOS Biology, back in July 2015[4]:

“Vaccines that keep hosts alive but still allow transmission could . . .  allow very virulent strains to circulate in a population. Here we show experimentally that immunization of chickens against Marek’s disease virus enhances the fitness of more virulent strains . . . . When vaccines prevent transmission, as is the case for nearly all vaccines used in humans, this type of evolution towards increased virulence is blocked. But when vaccines leak, allowing at least some pathogen transmission, they could create the ecological conditions that would allow hot strains to emerge and persist . . . [W]e report experiments with Marek’s disease virus in poultry that show that modern commercial leaky vaccines can have precisely this effect: they allow the onward transmission of strains otherwise too lethal to persist. Thus, the use of leaky vaccines can facilitate the evolution of pathogen strains that put unvaccinated hosts at greater risk of severe disease.”

The article also notes that:

“Efficacy and mode of action are key. If [a] vaccine is sterilizing, so that transmission is stopped, no evolution can occur. But if it is non-sterilizing, so that naturally acquired pathogens can transmit from immunized individuals (what we hereafter call a “leaky” vaccine), virulent strains will be able to circulate in situations in which natural selection would have once removed them . . .” 

It is of course obvious that local, regional and international officials recognise that the major Covid-19 vaccines (including the AstraZeneca used in Montserrat) are “non-sterilising.” That’s why the vaccinated have continued to be tested and quarantined. That’s why they must still wear face masks and do social distancing etc. That’s why it is admitted they can catch and infect others with the disease, though it is believed that the vaccines reduce the intensity of the disease. And, it is why, with Delta strain on the loose, we see significant numbers of cases where the “fully vaccinated” are becoming seriously ill or worse with Covid-19. So, again, as a recent report on Israel (which is now pushing third jabs) noted[5]:

“As of 15 August, 514 Israelis were hospitalized with severe or critical COVID-19 . . . 59% were fully vaccinated. Of the vaccinated, 87% were 60 or older. “There are so many breakthrough infections that they dominate and most of the hospitalized patients are actually vaccinated,”  says Uri Shalit, a bioinformatician at the Israel Institute of Technology (Technion) . . . “One of the big stories from Israel is:

‘Vaccines work, but not well enough.’” [“A grim warning from Israel: Vaccination blunts, but does not defeat Delta” Science Mag dot Org, August 16, 2021.]

In short, those who are “losing patience” with the unvaxxed have put the cart before the horse and are sliding into blaming the victim.

It was obvious from the beginning that the major anti-Covid-19 vaccines were “leaky” or “non-sterilising.” The researchers, regulators, and officials all knew that. We can take it to the bank that they knew about the Marek Virus evidence, that leaky vaxxes can turn the vaxxed into reservoirs for more dangerous, more infectious, fast-spreading strains than would naturally have come about. So, we know one reason they are desperate to get everyone jabbed, they fear a  truly lethal breakout strain, let’s call it Delta-plus. But we are not locked up in such a dilemma. There is the Ivermectin-based treatment option that should have been vigorously pushed as the treatment arm of our pandemic strategy for many months now.

But, someone following the WHO-FDA talking points,[6] may say, there’s no scientific evidence of that.

False, irresponsibly, destructively, inexcusably false, with lives on the line.

For one example, here are Omura et al from Japan, in a review article published in March this year[7] – yes, six months ago:

 “As of the 30th  of January 2021, a total of 91 trials in 27 countries has been recorded at these registration sites. There are 43 trials in phase 3 and 27 trials in phase 2, along with 17 observational studies. This includes 80 trials being conducted for therapeutic purposes and 11 for the purpose of preventing the onset of disease in close contacts and healthcare professionals. Furthermore,  by the 27th of February, the results of 42  clinical trials,  including approximately 15,000 patients (both registered and unregistered studies) have been subjected to a meta-analysis after exclusion of biasing factors. It was found that 83% showed improvements with early treatment,  51%  improved during late-stage treatment, and there was an 89% prevention of onset rate noted. This confirms the usefulness of ivermectin. Since it is a meta-analysis based on 42 test results, it is estimated that the probability of this comprehensive judgment being a mistake is as low  as one  in  four  trillion.” [The Japanese Journal of Antibiotics 74-1. Ivermectin emerged from research done in Japan.]

Investors and gamblers would salivate over an opportunity to bet with odds of four million, millions to one in favour of success. That is far more than adequate, robust scientific evidence to allow physicians to prescribe Ivermectin as a preventative, as a treatment to stamp out early-stage Covid-19, and even as part of protocols for seriously ill patients.[8] Those who have pretended otherwise have done the world a grave disservice.

It is time for a fresh conversation and a fresh approach to taming the pandemic before it becomes an even more destructive immune escape monster, say, Delta-plus. That is going to require that we back away from the WHO-FDA talking points and recognise the evidence for and legitimacy of treatments based on repurposed, proved medications such as Ivermectin.


[1]TMR https://www.themontserratreporter.com/failing-the-horse-de-wormer-test/

[2] See https://extension.psu.edu/mareks-disease-in-chickens-description-and-prevention

[3] See https://twitter.com/AlbertBourla/status/1433024869168558081?ref_src=twsrc%5Etfw

[4] See PLOS Biology https://journals.plos.org/plosbiology/article/info:doi/10.1371/journal.pbio.1002198

[5] TMR https://www.themontserratreporter.com/covid-19-vaccine-trends-concerns-and-misinformation/ see also https://www.sciencemag.org/news/2021/08/grim-warning-israel-vaccination-blunts-does-not-defeat-delta 

[6]See FLCCC point by point response https://covid19criticalcare.com/wp-content/uploads/2021/05/CLEAN-FLCCC-STATEMENT-AGAINST-THE-GLOBAL-IVERMECTIN-DISINFORMATION-CAMPAIGN-5.11.2021.pdf

[7] See JJA http://jja-contents.wdc-jp.com/pdf/JJA74/74-1-open/74-1_44-95.pdf

[8] See https://covid19criticalcare.com/covid-19-protocols/

Posted in Columns, COVID-19, De Ole Dawg, Environment, Featured, Features, Health, International, Local, News, Opinions, Regional, Science/Technology, Travel0 Comments

Methodist-Church-President

Main churches in Antigua support COVID-19 vaccinations – but where is the due diligence of their representation

Taken at another level when it comes to acts against humanity, these are well documented, even their claim to scientifically; but has the “church(es)” really checked the extent of the science and indeed their faith?

Bishop Everald Galbraith
Apostle Dr. Stephen Andrews

“…hand in hand with the state so that we can conquer this enemy together…”

This is the most frightening situation on our local front so far in this pandemic… but haven’t we been leading to this long?

R C Bishop Yanis

This is so so sad.

Not so much the encouragement, but what it represents in some disguise, if only to be carefully kind because of the apparent lack of due diligence by the churches, arguing the church must stand with science and faith.

Criminal acts against humanity, taking away people’s right of choice as to what ‘medication’ they take for something which carries minimal risks (Risks that are dishonestly represented at that) to theirs, or others’ lives.

Taking that right to choose that will ‘lawfully’ (but illegally) cause them to lose their livelihoods. Who thinks of the consequences of this? It is what the UN ICCPR is all about.

https://antiguanewsroom.com/seventh-day-adventist-churchs-stance-on-covid-19-vaccine/?fbclid=IwAR2V2s3_fzF47MF9FV0Jyii6yxE6_RvnT9hN94LcVXx4_KgP5-qzCn-xg60

Saying: “They are not the Biblical Mark of the Beast and they are safe and effective. That’s the stance of three prominent churches…in Antigua…”

Posted in Business/Economy/Banking, COVID-19, Featured, Local, News, Opinions, Regional, Science/Technology, TOURISM0 Comments

Mareks-Disease-in-Chickens-a-model-for-immunity-escape-Cr-Kumawat-Slideshare-2

“Losing patience” with the unvaxxed vs playing with the fire of “leaky” vaccines

Contribution 128/21 # 20 – (A special)

Have we put the cart before the horse with this pandemic, as leaky vaxxes can trigger the rapid spread of more dangerous strains? (And so, back to the value of Ivermectin.)

BRADES, Montserrat, September 12, 2021 – It is clear that some health authorities and governments across the Caribbean and wider world are beginning to “lose patience” with the not vaccinated. Such are widely viewed as misinformed, as idiotic,[1] stubborn, led by armchair instigators, as a dangerous source of spreading the pandemic, even as irresponsible and antisocial. Street talk and social media buzz show that some here in Montserrat are catching the impatience fever. We need to cool down the temperature and show why effective treatments such as Ivermectin are a key strategy.

Marek's Disease in Chickens, a model for immunity escape [Cr: Kumawat, Slideshare]
Marek’s Disease in Chickens, a model for immunity escape [Cr: Kumawat, Slideshare]

For, there is a Marek’s Disease Virus[2] shaped reason why Pfizer’s CEO recently touted his bright shiny new pill and finally publicly admitted that “Success against #COVID19 will likely require both vaccines & treatments.”[3] For, here in Montserrat, across the region and the world, we are playing with the fire of “leaky,” “non-sterilising” vaccines.

The case of Marek’s Disease Virus in chickens – yes, chickens – tells us why.

Andrew F Read et al. let the cat out of the bag,  in PLOS Biology, back in July 2015[4]:

“Vaccines that keep hosts alive but still allow transmission could . . .  allow very virulent strains to circulate in a population. Here we show experimentally that immunization of chickens against Marek’s disease virus enhances the fitness of more virulent strains . . . . When vaccines prevent transmission, as is the case for nearly all vaccines used in humans, this type of evolution towards increased virulence is blocked. But when vaccines leak, allowing at least some pathogen transmission, they could create the ecological conditions that would allow hot strains to emerge and persist . . . [W]e report experiments with Marek’s disease virus in poultry that show that modern commercial leaky vaccines can have precisely this effect: they allow the onward transmission of strains otherwise too lethal to persist. Thus, the use of leaky vaccines can facilitate the evolution of pathogen strains that put unvaccinated hosts at greater risk of severe disease.”

The article also notes that:

“Efficacy and mode of action are key. If [a] vaccine is sterilising, so that transmission is stopped, no evolution can occur. But if it is non-sterilising, so that naturally acquired pathogens can transmit from immunized individuals (what we hereafter call a “leaky” vaccine), virulent strains will be able to circulate in situations in which natural selection would have once removed them . . .” 

It is of course obvious that local, regional and international officials recognise that the major Covid-19 vaccines (including the AstraZeneca used in Montserrat) are “non-sterilising.” That’s why the vaccinated have continued to be tested and quarantined. That’s why they must still wear face masks and do social distancing etc. That’s why it is admitted they can catch and infect others with the disease, though it is hoped that the vaccines reduce the intensity of the disease. And, it is why, with Delta strain on the loose, we see significant numbers of cases where the “fully vaccinated” are becoming seriously ill or worse with Covid-19. So, again, as a recent report on Israel (which is now pushing third jabs) noted[5]:

“As of 15 August, 514 Israelis were hospitalized with severe or critical COVID-19 . . . 59% were fully vaccinated. Of the vaccinated, 87% were 60 or older. “There are so many breakthrough infections that they dominate and most of the hospitalized patients are actually vaccinated,”  says Uri Shalit, a bioinformatician at the Israel Institute of Technology (Technion) . . . “One of the big stories from Israel [is]: ‘Vaccines work, but not well enough.’” [“A grim warning from Israel: Vaccination blunts but does not defeat Delta” Science Mag dot Org, August 16, 2021.]

In short, those who are “losing patience” with the unvaxxed have put the cart before the horse and are sliding into blaming the victim.

It was obvious from the beginning that the major anti-Covid-19 vaccines were “leaky” or “non-sterilising.” The researchers, regulators, and officials all knew that. We can take it to the bank that they knew about the Marek Virus evidence, that leaky vaxxes can turn the vaxxed into reservoirs for more dangerous, more infectious, fast-spreading strains than would naturally have come about. So, we know one reason they are desperate to get everyone jabbed, they fear a  truly lethal breakout strain, let’s call it Delta-plus. But we are not locked up in such a dilemma. There is the Ivermectin-based treatment option that should have been vigorously pushed as the treatment arm of our pandemic strategy for many months now.

But, someone following the WHO-FDA talking points,[6] may say, there’s no scientific evidence of that.

False, irresponsibly, destructively, inexcusably false, with lives on the line.

For one example, here are Omura et al from Japan, in a review article published in March this year[7] – yes, six months ago:

 “As of the 30th  of January 2021, a total of 91 trials in 27 countries has been recorded at these registration sites. There are 43 trials in phase 3 and 27 trials in phase 2, along with 17 observational studies. This includes 80 trials being conducted for therapeutic purposes and 11 for the purpose of preventing the onset of disease in close contacts and healthcare professionals. Furthermore,  by the  27th   of  February,  the results of  42  clinical trials,  including approximately 15,000 patients (both registered and unregistered studies) have been subjected to a meta-analysis after exclusion of biasing factors. It was found that 83% showed improvements with early treatment,  51%  improved during late-stage treatment, and there was an 89% prevention of onset rate noted. This confirms the usefulness of ivermectin. Since it is a meta-analysis based on 42 test results, it is estimated that the probability of this comprehensive judgment being a mistake is as low  as  1  in  4  trillion.” [The Japanese Journal of Antibiotics 74-1. Ivermectin emerged from research done in Japan.]

Investors and gamblers would salivate over an opportunity to bet with odds of four million, millions to one in favour of success. That is far more than adequate, robust scientific evidence to allow physicians to prescribe Ivermectin as a preventative, as a treatment to stamp out early-stage Covid-19, and even as part of protocols for seriously ill patients.[8] Those who have pretended otherwise have done the world a grave disservice.


[1]TMR https://www.themontserratreporter.com/failing-the-horse-de-wormer-test/

[2] See https://extension.psu.edu/mareks-disease-in-chickens-description-and-prevention

[3] See https://twitter.com/AlbertBourla/status/1433024869168558081?ref_src=twsrc%5Etfw

[4] See PLOS Biology https://journals.plos.org/plosbiology/article/info:doi/10.1371/journal.pbio.1002198

[5] TMR https://www.themontserratreporter.com/covid-19-vaccine-trends-concerns-and-misinformation/ see also https://www.sciencemag.org/news/2021/08/grim-warning-israel-vaccination-blunts-does-not-defeat-delta 

[6]See FLCCC point by point response https://covid19criticalcare.com/wp-content/uploads/2021/05/CLEAN-FLCCC-STATEMENT-AGAINST-THE-GLOBAL-IVERMECTIN-DISINFORMATION-CAMPAIGN-5.11.2021.pdf

[7] See JJA http://jja-contents.wdc-jp.com/pdf/JJA74/74-1-open/74-1_44-95.pdf

[8] See https://covid19criticalcare.com/covid-19-protocols/

Posted in Columns, COVID-19, De Ole Dawg, Health, International, Local, News, Opinions, Regional, Science/Technology0 Comments

Slovakia

Pfizer and Merck are testing new Anti-COVID-19 pills

Contribution Part 126/21 # 18 (Special)

But, what does that suggest about the “bird already in the hand,” Ivermectin ?

BRADES, Montserrat, September 6, 2021 – According to a Sept 1, 2021, Reuters news feed,[1] “Pfizer Inc . . . and Merck & Co Inc . . .  announced . . .  new trials of their experimental oral antiviral drugs for COVID-19.” Reuters then continues: “ . . .  as the race to develop an easy-to-administer treatment for the potentially fatal illness heats up.” It seems, that Pfizer is testing effectiveness on 1,140 non-hospitalised patients “who are not at risk of severe illness.” Meanwhile, since July, Pfizer has been running another trial for patients “who are at high risk of becoming severely ill due to underlying health conditions such as diabetes.” Pfizer’s CEO, in a related tweet, stated that “Success against #COVID19 will likely require both vaccines & treatments.”[2]

All of this is indeed progress towards hopefully effective treatment.

However, such an announcement immediately raises the bird in the hand question: Ivermectin.

To see some of its force, let us note how the above fits in with a response to Jamaica’s Health Minister by a signatory of the Jamaican Doctors’ May 20th letter,[3] Charles Royes:

“Merck Pharmaceuticals, the original manufacturer of Ivermectin, no longer has a patent on production. They can no longer compete with low-cost manufacturers and have no financial interest in the drug. Instead, Merck has committed millions of dollars towards the development of another drug, Molnupiravir, which it hopes to market as a treatment for COVID-19. Early in the pandemic, Japan requested Merck to conduct clinical trials with Ivermectin and they declined.”

Plainly, if success against Covid-19 “will likely require both vaccines & treatments,” then, why was credible, adequate evidence of the effectiveness of Ivermectin[4] sidelined? And why is there a push to use disreputable tactics such as pushing the notion that it is horse deworming medicine . . . neatly omitting its Nobel Prize-winning performance against river blindness and evidence of antiviral and anti-inflammatory effects? Where, as that evidence was available in a key part in 2020, doesn’t that suggest that delays have cost us dear?

Of course, it has been convenient for many to dismiss that body of evidence as lacking credibility. The problem with that is, that in fact Ivermectin has been in use in several regions and has shown startling impact, on population-level data.

For just one example, as TMR discussed earlier,[5] here is the case of Slovakia – showing how case rates sharply taper off once Ivermectin was made widely available:

Similar patterns in Indonesia, India, Peru, and Mexico should give us pause before we take convenient dismissals at face value. Peru in particular gave the world a natural experiment across its 25 states, in a population of 33 million, as Dr. John Campbell of the UK summarised.

Dehli India is typical of Indian cases

Dehli, India is typical of Indian cases:

So, it is quite plausible that had Ivermectin been given a more fair hearing, we would have been able to put on the ground, treatments plus vaccine strategy many months ago. Recall, now that he has a competitor to Ivermectin (but one likely to make much bigger profits) Pfizer’s CEO has gone on record, that success against Covid-19 “will likely require both vaccines & treatments.”

We can call that an inadvertently telling admission against interest, so, likely to be true. Here, an admission that can hardly be a brand new realisation, as serious development work for the candidate oral drug has to have been ongoing since the early days of the crisis.  Likewise, for efforts by Merck, which also declined a Japanese request to study Ivermectin.

It is also worth the while to ponder a moment on why both treatments and vaccines are now on the table. For, the vaccines are non sterilising and seem to significantly fade after about six months. This is why there seems to be a push for third jabs, with Israel in the lead. Suggestions point to regular onward boosters. Such in turn points to selection pressure on the virus from the vaccines, leading to the emergence of breakout variants comparable to antibiotic or insecticide resistance. That is, we need effective anti-viral treatments to help stop the progress of infections, also further reducing spreading. And yes, the “fully vaccinated” can catch and spread the disease.

Again, as a report on Israel noted[6]:

“As of 15 August, 514 Israelis were hospitalized with severe or critical COVID-19 . . . 59% were fully vaccinated. Of the vaccinated, 87% were 60 or older. “There are so many breakthrough infections that they dominate and most of the hospitalized patients are actually vaccinated,”  says Uri Shalit, a bioinformatician at the Israel Institute of Technology (Technion) . . . “One of the big stories from Israel [is]: ‘Vaccines work, but not well enough.’” [“A grim warning from Israel: Vaccination blunts but does not defeat Delta” Science Mag dot Org, August 16, 2021.]


[1] See https://www.reuters.com/business/healthcare-pharmaceuticals/pfizer-starts-dosing-patients-oral-covid-19-drug-trial-2021-09-01/

[2] See https://twitter.com/AlbertBourla/status/1433024869168558081?ref_src=twsrc%5Etfw

[3] TMR https://www.themontserratreporter.com/jamaican-doctors-stage-an-ivermectin-uprising/

[4] See https://covid19criticalcare.com/wp-content/uploads/2020/11/FLCCC-Ivermectin-in-the-prophylaxis-and-treatment-of-COVID-19.pdf

[5] TMR https://www.themontserratreporter.com/ivermectin-some-population-level-evidence/

[6] TMR https://www.themontserratreporter.com/covid-19-vaccine-trends-concerns-and-misinformation/ see also https://www.sciencemag.org/news/2021/08/grim-warning-israel-vaccination-blunts-does-not-defeat-delta 

Posted in Columns, COVID-19, De Ole Dawg, Featured, Health, International, Local, Regional, Science/Technology0 Comments

promoting-horse-medicine-ivermectin

Failing the “horse de-wormer” test

Contribution – 124/21 # 17)

Is Ivermectin simply an anti-parasitic for animals that is being misused due to anti-vax propaganda?

Ivermectin paste, veterinary formulation for de-worming horses. Notice, the other ingredients.

BRADES, Montserrat, September 6, 2021 – Indeed, Ivermectin is often used to de-worm horses, dogs, etc, and as an antiparasitic. That is the germ of truth that has been used to lend credibility to a smear job, [yes], that ignorant people following unscientific anti-vax misinformation are dosing themselves with a useless, toxic medicine intended for animals. It is even true that some desperate people have indeed apparently taken horse-sized doses of veterinary formulations, obviously without a doctor’s supervision. For, a horse might weigh 1,200 lbs, a big person perhaps 250. So, a horse-sized dose would then be maybe four or more times that for a human being and could easily have toxic effects.  But, that’s not even near to being the whole story.

And the push to suggest that it is, is instead a truth test that far too many are failing.

Ivermectin paste, veterinary formulation for de-worming horses. Notice, the other ingredients.
A Cartoon used to promote the notion that Ivermectin is a misused de-wormer for horses (and yes, this is apple flavour here)

First, those who promote or publish the atrocity tale in the media. As, there is the readily accessed ¾ of the story that could easily have been found, starting with its Nobel Prize-winning role in dealing with human river blindness. Yes, Ivermectin has been used successfully and safely with people (under medical supervision) for over thirty years. 

Failure to acknowledge that is without excuse for any significant media house, official, or spokesperson.

Second, if we fail to take a critically aware view of such voices, ironically, we are in danger of swallowing or even spreading misinformation ourselves.

In either case, credibility is broken.

We can also provide facts from relevant scientific literature. For example, as Dr. Pierre Kory and others note in a 2021 American Journal of Therapeutics article[1]:

“Ivermectin [was] introduced as a veterinary drug [in the early 1980s] . . .  it soon made historic impacts in human health, improving the nutrition, general health, and well-being of billions of people worldwide ever since it was first used to treat onchocerciasis (river blindness) in humans in 1988 . . . Ivermectin’s impacts in controlling onchocerciasis and lymphatic filariasis, diseases which blighted the lives of billions of the poor and disadvantaged throughout the tropics, is why its discoverers were awarded the Nobel Prize in Medicine in 2015 and the reason for its inclusion on the World Health Organization’s (WHO) ‘List of Essential Medicines.’ ”

In a 2020 [Nature] Journal of Antibiotics article,[2] Fatemeh Heidary and Reza Gharebaghi add:

“Studies revealed that ivermectin as a broad-spectrum drug with high lipid [ = fat] solubility possesses numerous effects on parasites, [1, 3] nematodes, arthropods, flavivirus, mycobacteria, and mammals through a variety of mechanisms. In addition to having antiparasitic and antiviral effects, this drug also causes immunomodulation in the host. Studies have shown its effect on inhibiting the proliferation of cancer cells, as well as regulating glucose and cholesterol in animals.” [Pardon the technical language.]

That is why Ivermectin was a reasonable drug to test as a possible repurposed treatment for effectiveness against Covid-19. As we have already seen here at TMR, it is credibly effective, which is why leading Doctors in Jamaica publicly advised their Minister of Health[3]:

“[w]hile Ivermectin[‘s] efficacy has been demonstrated in the management of all stages of Covid, we draw particular attention to its use in the early stage of the disease . . . In our carefully considered opinion, the available data on Ivermectin is quite adequate.[4] There is no need to await the outcome of further trials. Any call for local trials prior to approval is unnecessary, as neither time, resources, nor ethical approval would permit. We need not await WHO approval of the use of Ivermectin for the treatment of Covid-19. The WHO, unfortunately, has been slow, and sometimes incorrect, in its assessment and advice on various aspects of the pandemic and specifically so in relation to its current stance on Ivermectin. Several medical jurisdictions in various countries are proceeding to include Ivermectin in their Covid-19 treatment strategies.”

A summary of such evidence has been made by Dr. Kory and others.[5] Reportedly, Ivermectin:

 – inhibits the replication of many viruses, including influenza, Zika, Dengue, and others

 – inhibits SARS-CoV-2 replication and binding to host tissue

 – has potent anti-inflammatory properties

 – significantly diminishes viral load and protects against organ damage in multiple animal models

– prevents transmission and development of COVID-19 disease in those exposed to infected patients

 – hastens recovery and prevents deterioration in patients with mild to moderate disease treated early

 – hastens recovery and avoidance of ICU admission and death in hospitalized patients

– reduces mortality in critically ill patients with COVID-19

– leads to striking reductions in case-fatality rates in regions with widespread use

 safety, availability, and [low] cost . . .  is nearly unparalleled

– near nil drug interactions along with only mild and rare side effects observed in almost 40 years of use and billions of doses administered

There is a fair amount of published evidence for that [see the report], there is a growing body of cases and studies, and there are population-level results. No wonder the Jamaican Doctors make a pointed contrast:

“Emergency Use Approval has been granted from health regulatory authorities, including WHO, and FDA, for the clinical use of other treatment regimes (Remdesivir, Convalescent Plasma, Monoclonal Antibodies, etc.) with far less research and data support compared with Ivermectin.”

A Cartoon used to promote the notion that Ivermectin is a misused de-wormer for horses (and yes, this is apple flavour here)


[1] See https://journals.lww.com/americantherapeutics/fulltext/2021/06000/review_of_the_emerging_evidence_demonstrating_the.4.aspx

[2] See https://www.nature.com/articles/s41429-020-0336-z.pdf

[3] TMR https://www.themontserratreporter.com/jamaican-doctors-stage-an-ivermectin-uprising/ cf Gleaner https://jamaica-gleaner.com/article/news/20210520/doctors-back-ivermectin-covid-19-fight 

[4] TMR note, e.g. see https://covid19criticalcare.com/wp-content/uploads/2020/11/FLCCC-Ivermectin-in-the-prophylaxis-and-treatment-of-COVID-19.pdf 

[5] See https://covid19criticalcare.com/wp-content/uploads/2020/11/FLCCC-Ivermectin-in-the-prophylaxis-and-treatment-of-COVID-19.pdf pp. 3 – 4

Posted in Columns, COVID-19, De Ole Dawg, Featured, Health, International, Local, News, OECS, Opinions, Regional, Science/Technology0 Comments

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